CRASH-3 deserves unending respect. It is the most impressive study in the history of head injury, pitting tranexamic acid against placebo in more than ten thousand subjects.
Yeah. Ten thousand. Indeed for blunt trauma (CRASH2, 2010) and postpartum hemorrhage (WOMAN, 2017) the same researchers enrolled twenty thousand subjects—in each trial. CRASH-3 is therefore the third mega-trial from this record-setting consortium.
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